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The Evolution of Drosophila melanogaster as a Model for Alcohol Research In this paper, researchers investigate the relationship between ethanol and Drosophila in an ecological and evolutionary perspective. Fruit flies have many adaptations due to a prevalence of ethanol in their environment. Typically fruit flies are found near ripe food which can hold up to 5% ethanol. Flies metabolize ethanol and use it as an energy source. Fruit flies also contain a smaller version of Alcohol Dehydrogenase (ADH) which differs slightly from the longer vertebrate version of the protein, indicating that fruit flies had an earlier ecological change to ethanol in ripe fruit. ADH is also necessary for survival on ethanol foods. Researchers found that having ethanol as the only source of calories induced a longer survival rate indicating that ethanol is a strong source of calories for Drosophila. Behavioral studies of Drosophila have shown that fruit flies with a longer and stronger exposure to ethanol ...
Genetic studies of alcohol dependence in the context of the addiction cycle Alcohol dependence is heritable. Two factor contribute to alcohol dependence - environmental conditions, and genes. It is estimated that genes contribute to about 50-60% of the phenotype.It is hard to nail down the exact genes because everything is heterogenous. Researchers study twin studies and adoption data to define the genetic components of alcohol dependence. Both twin and adoption studies show high correlation between family members and the participants susception to alcohol dependency. Research then ran an GWAS (genome wide association study) and found multiple genetic variants that contribute to alcoholism.
Lindy Matthews' long-time project, continued after she left by Hailey Wilcox, was just accepted! This paper is huge! It shows:
Our new paper, led by undergraduate Amber Walters and in collaboration with Drs. Peter Newell, Angela Douglas, and Paul Schmidt, was published in Molecular Ecology.
We had great news, finding out that six lab members received CURA awards in 2019.
Our collaboration with U. Pennsylvania and Stanford just came out this week in PNAS! We showed we could manipulate the bacteria in flies evolving in outdoor environments, and the manipulations confirmed that variation in the microbiota changes the genetics of the host. Co-authors Rachel Hughes, Dallin Lowder, and Skyler Lemmon (undergraduates in the lab) were instrumental in manipulating and measuring the microbiota changes and effects. Check out their great work!
Shayna spent 8 weeks at XX working on the project: Cloning and Purification of regulatory protein PhoP of Mycobacterium tuberculosis H37Rv.
We had a great time at Drosophila 2019, including poster presentations from Rachel, Tanner, Sarah, and Hailey: And the gut dinner.